Ladies and gentlemen,

Please find enclosed three new papers dealing with PLT VASP/P2Y12 kit (7014) from BioCytex.

• Increased Platelet Inhibition After Switching From Maintenance Clopidogrel to Prasugrel in Patients with Acute Coronary Syndromes. Results of the SWAP (SWitching Anti Platelet) Study. Angiolillo D.J.et al., J Am Coll Cardiol 2010;56:1017-23.
  
  Conclusions : For patients receiving maintenance clopidogrel therapy after an ACS event, switching from clopidogrel to prasugrel is associated with a further reduction in platelet function by 1 week using prasugrel MD or within 2 h with the administration of a prasugrel LD.
  
  
• Inhibitory Effects of Ticagrelor Compared with Clopidogrel on Platelet Function in Patients with Acute Coronary Syndromes The PLATO (PLATelet inhibition and patient Outcomes) PLATELET Substudy. Storey R.F. et al., JACC 2010 in press.
  
  Conclusions : Ticagrelor achieves greater antiplatelet effect than clopidogrel in patients with acute coronary syndromes, both in the first hours of treatment and during maintenance therapy.

• Consensus and Future Directions on the Definition of High On-Treatment Platelet Reactivity to Adenosine Diphosphate. Bonello L et al., J Am Coll Cardiol. 2010, 56(12):919-33.
  
  A very good consensus paper : "At the present time, high on-treatment platelet reactivity in the setting of PCI has been defined by ROC analyses using the following criteria: 1) PRI>50% by VASP-P analysis; 2)>235 to 240 P2Y12 reaction units by VerifyNow P2Y12 assay; 3) >46% maximal 5-µmol/l ADP-induced aggregation; and 4) >468 arbitrary aggregation units/min in response to ADP by Multiplate analyzer. However, there are no large-scale clinical studies to date demonstrating that the adjustment of antiplatelet therapy based on any of these cut points improves clinical outcomes." .

MILAN ANALYTICA is the exclusive Swiss distributor for BioCytex products (monoclonal antibodies against CD markers and kits for platelet diagnosis).

Please do not hesitate to contact us for further information.

Thank you for your attention and best regards

Julia Hirtle
Sales and Marketing Manager Distribution